PC-IRV or pressure-controlled ventilation with sufficient inspiratory time might reduce the VD phys. ![]() VD phys represents the overall ventilatory efficiency, including circulatory dynamics, and a total of ventilation/perfusion ( ) mismatch. However, serum cytokine levels are affected not only by the ventilator setting, but also by duration, surgical invasion, bleeding, and any stress to the patient. ![]() However, another randomized controlled study reported no differences between the lung-protective properties of PC-IRV and volume-control ventilation (VCV) when performed for >2 h in robot-assisted laparoscopic radical prostatectomy, as determined by the changes in serum cytokine levels. We believe that PC-IRV might be a lung-protective ventilation strategy. Previously, we studied the changes in dead space components within a short duration (30 min) of each ventilator mode using a cross-over study design, and reported that pressure-controlled inverse ratio ventilation (PC-IRV) reduces the physiological dead space (VD phys).
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